ImportError: No module named _ssl

Did you build the Python from source? If so, you need the --with-ssl option while building.

Unrelated to the original question, but because this is the first Google result... I hit this on Google AppEngine and had to add:

libraries:
- name: ssl
  version: latest

to app.yaml per: https://cloud.google.com/appengine/docs/python/sockets/ssl_support

Please NOTE: This seems to work upto Python version 2.7.9 but not for 2.7.10 or 2.7.11.

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