Is it currently impossible to publish UWP apps to Store when using F#?
At this time [Sep 29 '17] it appears that .NET Native, the technology used to pre-compile UWP apps, as I understand it, still does not support F#.
Here's the GH issue on this, with a linked work-around for publishing Win32 and .NET apps--but I suspect if you want a UWP app, no such luck: https://github.com/Microsoft/visualfsharp/issues/1096
Update 1/23/2019
It is possible to use .net native with F# UWP but, it is not officially supported.
https://github.com/dotnet/corert/issues/6055
We can confirm that .Net Native compilation works now on Store compilation machines, and we have released our beta F# app on the store (link).
https://www.reddit.com/r/fsharp/comments/acj7dn/f_winrtuwp_apps_on_net_native_are_now_releasable/?utm_source=reddit-android
Screencap for posterity (should the link change)