Is there a way to check if WPF is currently executing in design mode or not?

There are other (maybe newer) ways of specifying design-time data in WPF, as mentioned in this related answer.

Essentially, you can specify design-time data using a design-time instance of your ViewModel:

d:DataContext="{d:DesignInstance Type=v:MySampleData, IsDesignTimeCreatable=True}"

or by specifying sample data in a XAML file:

d:DataContext="{d:DesignData Source=../DesignData/SamplePage.xaml}">

You have to set the SamplePage.xaml file properties to:

BuildAction:               DesignData
Copy to Output Directory:  Do not copy
Custom Tool:               [DELETE ANYTHING HERE SO THE FIELD IS EMPTY]

I place these in my UserControl tag, like this:

<UserControl
    ...
    xmlns:d="http://schemas.microsoft.com/expression/blend/2008" 

    xmlns:d="http://schemas.microsoft.com/expression/blend/2008"
    ...
    d:DesignWidth="640" d:DesignHeight="480"
    d:DataContext="...">

At run-time, all of the "d:" design-time tags disappear, so you'll only get your run-time data context, however you choose to set it.

Edit You may also need these lines (I'm not certain, but they seem relevant):

xmlns:mc="http://schemas.openxmlformats.org/markup-compatibility/2006" 
mc:Ignorable="d" 

I believe you are looking for GetIsInDesignMode, which takes a DependencyObject.

Ie.

// 'this' is your UI element
DesignerProperties.GetIsInDesignMode(this);

Edit: When using Silverlight / WP7, you should use IsInDesignTool since GetIsInDesignMode can sometimes return false while in Visual Studio:

DesignerProperties.IsInDesignTool

Edit: And finally, in the interest of completeness, the equivalent in WinRT / Metro / Windows Store applications is DesignModeEnabled:

Windows.ApplicationModel.DesignMode.DesignModeEnabled

public static bool InDesignMode()
{
    return !(Application.Current is App);
}

Works from anywhere. I use it to stop databound videos from playing in the designer.

You can do something like this:

DesignerProperties.GetIsInDesignMode(new DependencyObject());