NoClassDefFoundError below SDK 21

There are three ways how this is going to work.

1. As @FireZenk noted you can declare this class as the application in your AndroidManifest.xml.

<application android:name="android.support.multidex.MultiDexApplication">

And actually with the android grade plugin version 0.14.0 and build tools version 21.1.0 when you specify the multiDexEnabled true in the defaultConfig, ProductFlavor, or BuildTypethen it automatically includes dependence to the com.android.support:multidex:1.0.0. You can check that with the androidDependencie task or you run ./gradlew -q android:dependencies command (android: is my android module). So there is no need to explicitly add the

compile 'com.android.support:multidex:1.0.0'

If you have extended Application class in your app:

2. Define that your Application extends MultiDexApplication class, like:

public class MyApplication extends MultiDexApplication {
    ...
}

or like @user2700475 posted

3. Have your Application override attachBaseContext:

public class MyApplication extends Application {
    @Override
    protected void attachBaseContext(Context base) {
    super.attachBaseContext(base);
    MultiDex.install(this);}
}

With the help of previous answers I manage to find the solution to this problem. I just want to put all this together.

I resolved the issue by adding this to my Application Class.

@Override
protected void attachBaseContext(Context base) {
    super.attachBaseContext(base);
    MultiDex.install(this);
}

Seems to be neccessary for android versions prior 5.