Notepad++: Capitalize first letter by Shortcut?

Well, you can install the TextFX plugin and apply Sentense case. Here you have some tricks (including this one). http://a4apphack.com/featured/tricks-with-notepad

This can be easily done if the first letters are latin characters. But this method does not work with non-latin (for example cyrillic) characters. Just press Ctrl+F, enable "Regular Expression" checkbox, and search for

^(.)

replace with (Replace All)

\u\1

". matches newline" checkbox has to be unchecked