Python Tkinter clearing a frame

https://anzeljg.github.io/rin2/book2/2405/docs/tkinter/universal.html

w.winfo_children()
Returns a list of all w's children, in their stacking order from lowest (bottom) to highest (top).

for widget in frame.winfo_children():
    widget.destroy()

Will destroy all the widget in your frame. No need for a second frame.

For clear frame, first need to destroy all widgets inside the frame,. it will clear frame.

import tkinter as tk
from tkinter import *
root = tk.Tk()

frame = Frame(root)
frame.pack(side="top", expand=True, fill="both")

lab = Label(frame, text="hiiii")
lab.grid(row=0, column=0, padx=10, pady=5)

def clearFrame():
    # destroy all widgets from frame
    for widget in frame.winfo_children():
       widget.destroy()
    
    # this will clear frame and frame will be empty
    # if you want to hide the empty panel then
    frame.pack_forget()

frame.but = Button(frame, text="clear frame", command=clearFrame)
frame.but.grid(row=0, column=1, padx=10, pady=5)

# then whenever you add data in frame then you can show that frame
lab2 = Label(frame, text="hiiii")
lab2.grid(row=1, column=0, padx=10, pady=5)
frame.pack()
root.mainloop()

pack_forget and grid_forget will only remove widgets from view, it doesn't destroy them. If you don't plan on re-using the widgets, your only real choice is to destroy them with the destroy method.

To do that you have two choices: destroy each one individually, or destroy the frame which will cause all of its children to be destroyed. The latter is generally the easiest and most effective.

Since you claim you don't want to destroy the container frame, create a secondary frame. Have this secondary frame be the container for all the widgets you want to delete, and then put this one frame inside the parent you do not want to destroy. Then, it's just a matter of destroying this one frame and all of the interior widgets will be destroyed along with it.