replace() method not working on Pandas DataFrame

Given that this is the top Google result when searching for "Pandas replace is not working" I'd like to also mention that:

replace does full replacement searches, unless you turn on the regex switch. Use regex=True, and it should perform partial replacements as well.

This took me 30 minutes to find out, so hopefully I've saved the next person 30 minutes.

You need to assign back

df = df.replace('white', np.nan)

or pass param inplace=True:

In [50]:
d = {'color' : pd.Series(['white', 'blue', 'orange']),
   'second_color': pd.Series(['white', 'black', 'blue']),
   'value' : pd.Series([1., 2., 3.])}
df = pd.DataFrame(d)
df.replace('white', np.nan, inplace=True)
df

Out[50]:
    color second_color  value
0     NaN          NaN    1.0
1    blue        black    2.0
2  orange         blue    3.0

Most pandas ops return a copy and most have param inplace which is usually defaulted to False