Singleton for Application Configuration
Use dependency injection to inject the single configuration object into any classes that need it. This way you can use a mock configuration for testing or whatever you want... you're not explicitly going out and getting something that needs to be initialized with configuration files. With dependency injection, you are not passing the object around either.
I think an application configuration is an excellent use of the Singleton pattern. I tend to use it myself to prevent having to reread the configuration each time I want to access it and because I like to have the configuration be strongly typed (i.e, not have to convert non-string values each time). I usually build in some backdoor methods to my Singleton to support testability -- i.e., the ability to inject an XML configuration so I can set it in my test and the ability to destroy the Singleton so that it gets recreated when needed. Typically these are private methods that I access via reflection so that they are hidden from the public interface.
EDIT We live and learn. While I think application configuration is one of the few places to use a Singleton, I don't do this any more. Typically, now, I will create an interface and a standard class implementation using static, Lazy<T>
backing fields for the configuration properties. This allows me to have the "initialize once" behavior for each property with a better design for testability.