The game freezes sometimes when I Exit To Desktop. How to regain control?

The game crashes when exiting to desktop while in a game. Here are a couple of methods.

Method 1: Exit to the main menu instead of quitting to desktop from a running game.

Method 2: If Stuck!

Here is a method to force the civilization game to close by ending its process.

(Bring up task manager)    
Press CONTROL-SHIFT-ESC 
OR
CONTROL-ALT-DEL and then select it from the list.

You may need to click "More Details" at the bottom if that is showing as an option.
Goto details tab
Find process CivilizationVI.exe
Right click, End Process

Perhaps to be done now as it will help later as I have had the task manager appear under the game (dumb).

Bring up the task manager.

Under options menu, enable ALWAYS ON TOP

Once you have done this once or twice or know how to use the task manager, it will become second nature.