Troubles remote debugging a .Net Application "no symbols have been loaded for this document."

The problem was that the PDB files have to be placed at the same folder both on the VM and the host.

I had similar issue and I did the following: Debug=>Options=>General => Remove the check mark for "Enable Just My Code" This worked for me..

Reference: https://developercommunity.visualstudio.com/comments/114735/view.html

Another potential cause of the problem is a version mismatch between the code running on the server and the local code. I was able to fix this by redeploying the local code to the server.