Typescript interface default values

You can't set default values in an interface, but you can accomplish what you want to do by using Optional Properties (compare paragraph #3):

https://www.typescriptlang.org/docs/handbook/interfaces.html

Simply change the interface to:

interface IX {
    a: string,
    b?: any,
    c?: AnotherType
}

You can then do:

let x: IX = {
    a: 'abc'
}

And use your init function to assign default values to x.b and x.c if those properies are not set.

You can implement the interface with a class, then you can deal with initializing the members in the constructor:

class IXClass implements IX {
    a: string;
    b: any;
    c: AnotherType;

    constructor(obj: IX);
    constructor(a: string, b: any, c: AnotherType);
    constructor() {
        if (arguments.length == 1) {
            this.a = arguments[0].a;
            this.b = arguments[0].b;
            this.c = arguments[0].c;
        } else {
            this.a = arguments[0];
            this.b = arguments[1];
            this.c = arguments[2];
        }
    }
}

Another approach is to use a factory function:

function ixFactory(a: string, b: any, c: AnotherType): IX {
    return {
        a: a,
        b: b,
        c: c
    }
}

Then you can simply:

var ix: IX = null;
...

ix = new IXClass(...);
// or
ix = ixFactory(...);

Can I tell the interface to default the properties I don't supply to null? What would let me do this

No. You cannot provide default values for interfaces or type aliases as they are compile time only and default values need runtime support

Alternative

But values that are not specified default to undefined in JavaScript runtimes. So you can mark them as optional:

interface IX {
  a: string,
  b?: any,
  c?: AnotherType
}

And now when you create it you only need to provide a:

let x: IX = {
    a: 'abc'
};

You can provide the values as needed:

x.a = 'xyz'
x.b = 123
x.c = new AnotherType()

While @Timar's answer works perfectly for null default values (what was asked for), here another easy solution which allows other default values: Define an option interface as well as an according constant containing the defaults; in the constructor use the spread operator to set the options member variable

interface IXOptions {
    a?: string,
    b?: any,
    c?: number
}

const XDefaults: IXOptions = {
    a: "default",
    b: null,
    c: 1
}

export class ClassX {
    private options: IXOptions;

    constructor(XOptions: IXOptions) {
        this.options = { ...XDefaults, ...XOptions };
    }

    public printOptions(): void {
        console.log(this.options.a);
        console.log(this.options.b);
        console.log(this.options.c);
    }
}

Now you can use the class like this:

const x = new ClassX({ a: "set" });
x.printOptions();

Output:

set
null
1