Utf8_general_ci or utf8mb4 or...?

MySQL's utf32 and utf8mb4 (as well as standard UTF-8) can directly store any character specified by Unicode; the former is fixed size at 4 bytes per character whereas the latter is between 1 and 4 bytes per character.

utf8mb3 and the original utf8 can only store the first 65,536 codepoints, which will cover CJVK (Chinese, Japanese, Vietnam, Korean), and use 1 to 3 bytes per character.

utf16 uses 2 bytes for the first 65,536 codepoints, and 4 bytes for everything else.

As for fonts, that's strictly a visual thing.

"The Absolute Minimum Every Software Developer Absolutely, Positively Must Know About Unicode and Character Sets (No Excuses!)"

See also MySQL documentation for Unicode support.