What is the python keyword "with" used for?

In python the with keyword is used when working with unmanaged resources (like file streams). It is similar to the using statement in VB.NET and C#. It allows you to ensure that a resource is "cleaned up" when the code that uses it finishes running, even if exceptions are thrown. It provides 'syntactic sugar' for try/finally blocks.

From Python Docs:

The with statement clarifies code that previously would use try...finally blocks to ensure that clean-up code is executed. In this section, I’ll discuss the statement as it will commonly be used. In the next section, I’ll examine the implementation details and show how to write objects for use with this statement.

The with statement is a control-flow structure whose basic structure is:

with expression [as variable]:
    with-block

The expression is evaluated, and it should result in an object that supports the context management protocol (that is, has __enter__() and __exit__() methods).

Update fixed VB callout per Scott Wisniewski's comment. I was indeed confusing with with using.

Explanation from the Preshing on Programming blog:

It’s handy when you have two related operations which you’d like to execute as a pair or more, with a block of code in between. The classic example is opening a file, manipulating the file, then closing it:

 with open('output.txt', 'w') as f:
     f.write('Hi there!')

The above with statement will automatically close the file after the nested block of code. (Continue reading to see exactly how the close occurs.) The advantage of using a with statement is that it is guaranteed to close the file no matter how the nested block exits. If an exception occurs before the end of the block, it will close the file before the exception is caught by an outer exception handler. If the nested block were to contain a return statement, or a continue or break statement, the with statement would automatically close the file in those cases, too.