Windows Storage Spaces, can I stripe across 3 disks and on top mirror to a 4th disk?

I have 4 HDD drives and want to maximize read performance with 1 level of resiliency.

You can deploy MSFT's equivalent of RAID10. Please see what columns have to do with redundancy and performance.

https://social.technet.microsoft.com/wiki/contents/articles/11382.storage-spaces-frequently-asked-questions-faq.aspx#What_are_columns_and_how_does_Storage_Spaces_decide_how_many_to_use