Input List Selection Changed Event

The input event should work for what you need. As I understand, you can't use a datalist directly, but it is connected to an input by the list attribute. This event binding would go on that input:

document.getElementById('browsers-input').addEventListener('input', function (event) {
   if (event.inputType == 'insertReplacementText')
       console.log('autocomplete option selected'); 
});

http://jsfiddle.net/vccfv/

To get the same effect of "Explosion Pills" solution using JQuery style:

$("#browsers-input").on("input", MySuperFunction);

Usin jQuery you could use .change http://jquery.com/

$('datalist#browsers').change(MySuperFunction);

or

$('datalist#browsers').change(function(){
  // stuff
});