iOS Simulator - offline mode

Install Little Snitch and temporarily block all connections from iOS Simulator when the dialog comes up.

Install Network Link Conditioner from Apple. And you will have possibility to change to offline mode.

There's a tool called "Network Link Conditioner" but it seems that its only for OX Lion and xCode 4.1+ installed. Take look at: http://osxdaily.com/2011/08/10/simulate-internet-connectivity-bandwidth-speeds-network-link-conditioner/ - i use it almost everyday :)

If you set os x offline, the iPad simulator will be offline. Otherwise, no.