Is it possible to have different applications set to different locales?

The application itself would need to support configuring a locale different from the systems. The system locale is a single global default setting for all apps.

You can have what you need with this:

• Create a new local user.
• Log in with that user and change the Windows language of that account to which you need.
• Log out
• Log in with your usual user.
• Run the application you want to see in a different language with the "Run As" method. (Shift+right click on the shortcut and select Run as different user).