Is there big syntax differences between Clojure and Lisp

90% of what you learn while studying your first Lisp will carry over to your next.

There are not big syntax differences (mostly because Lisp family languages have almost no syntax), but there are certainly differences in other areas. Clojure has a lot of modern programming features particularly suited to high scalability (actors, references, etc) that are not present as such in a "classic" Lisp (such as Common Lisp).

Clojure is an active, well supported dialect of Lisp. If you want to learn a Lisp, you can't really go wrong with Clojure.

You may find more information in the answers to Which Lisp should I learn? .