Java Regex include all letters of the alphabet except certain letters

'&&' didn't work for me,

used: (?:(?![IVX])[A-Z])

You can use the && operator to create a compound character class using subtraction:

String regex = "[A-Z&&[^IVX]]+";

Just use a negative lookahead in your pattern.

Pattern pattern = Pattern.compile("^(?:(?![IVX])[A-Z])+$");

DEMO

You could simply specify character ranges inside your character class:

[A-HJ-UWYZ]+

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