jqeury ajax select2 manual code example

Example 1: select2 clear options

Remove the selected options : 
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$('#mySelect2').val(null).trigger('change');

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Completly remove the select2 initialization :
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$('#payment_method').html('').select2({data: [{id: '', text: ''}]});

Example 2: select 2 select a value

SELECT2 V4 :
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For select2 v4 you can append directly an option/s as follow:

<select id="myMultipleSelect2" multiple="" name="myMultipleSelect2[]">
    <option value="TheID" selected="selected">The text</option>                                                                   
</select>

Or with JQuery:
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var $newOption = $("<option selected='selected'></option>").val("TheID")
					.text("The text")
 
$("#myMultipleSelect2").append($newOption).trigger('change');

other example :
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$("#myMultipleSelect2").val(5).trigger('change');