Key to mute my Skype mic?
When Skype is focused, Command+Shift+M toggles the microphone.
Ctrl+Alt+Command+ ↑ also mutes the microphone for me, and works globally. However, it's not a toggle; as noted below, it switches to Push To Talk mode, in which the mic is muted by default but will be unmuted as long as Ctrl+Alt+Command+ ↑ is pressed.
I'm on OS X 10.8, with the latest version of Skype as of 10/16/2012.
While the application does not have a built in keyboard shortcut for it you can add one using the Keyboard Shortcuts feature in the Keyboard Preference Pane in System Preferences.
- Open System Preferences
- Open Keyboard
- Change to the Keyboard Shortcuts section (If using Snow Leopard click Application Shortcuts on the left side)
- Press the '+' button.
- Select Skype as the Application
- Menu Title: "Mute"
- Choose a Keyboard Shortcut (eg. Command-Option-M as Command-M is used for minimize.)
- Press OK, close System Preferences and restart Skype if it was open.
You can use spacebar to toggle mute/unmute.
Credit: http://forum.skype.com/index.php?showtopic=70965&view=findpost&p=2216171