$\mathbb{Z}G$ (left) Noetherian$\Rightarrow$ $\ell^1(G)$ is a flat (right) $\mathbb{Z}G$-module?

Here are a few observations that are too long for a comment but don't provide a full answer by any means.

As Peter Samuelson observed left-right questions aren't significant in this setting since $\mathbb{Z}G$ is isomorphic to $\mathbb{Z}G^{op}$.

Also, note that $\mathbb{C}G$ is a flat $\mathbb{Z}G$-module since $\mathbb{C}$ is a flat $\mathbb{Z}$ module. Thus, by standard base change arguments, to prove that $l^1(G)$ is flat over $\mathbb{Z}G$ it would suffice to prove that it is flat over $\mathbb{C}G$. At least in the case $G$ is polycyclic-by-finite, $\mathbb{C}G$ will also be (left and right) Noetherian.

Now I'm going to restrict to the case $G=\mathbb{Z}$, so $\mathbb{C}G\cong \mathbb{C}[x,x^{-1}]$, the ring of Laurent polynomials in $x$. This ring is a principal ideal domain.

Now I refer to Weibel's Introduction to homological algebra (CUP) Proposition 3.2.4. A left $R:=\mathbb{C}[x,x^{-1}]$-module $B$ is flat as such if and only if $\mathrm{Tor}_1^R(R/I,B)=0$ for every right ideal $I$ of $R$.

But we've already observed that every (right) ideal $I$ is of the form $fR$ in this case, and (for $f\neq 0$), we can compute $\mathrm{Tor}_1^R(R/fR,B)$ explicitly as $[f]B :=\{ b\in B\mid fb=0\}$.

In other words, to answer your question positively for $G=\mathbb{Z}$ it suffices to prove that $l^1(G)$ has no elements killed by $f$ for any non-zero $f\in \mathbb{C}G$. I think it should be possible to prove this by elementary arguments although I haven't even begun to check.

The general answer is no for my question.

For example, for $G=\mathbb{Z}^2\rtimes\mathbb{Z}$ with exponential growth rate, $\ell^1(G)$ is not flat over $\mathbb{Z}G$, the proof is based on rather elementary calculation. But it is too long to be present here..

The point is to find $f\in\mathbb{Z}G\cap\ell^1(G)^{\times}$, find $h\in\mathbb{Z}G$, and do calculation to show for any $t\in\mathbb{Z}G$ with $th\in\mathbb{Z}Gf$, $t\not\in\ell^1(G)^{\times}$. Then we have $0\to\frac{\mathbb{Z}Gf+\mathbb{Z}Gh}{\mathbb{Z}Gf}\to\frac{\mathbb{Z}G}{\mathbb{Z}Gf}$ fails the flatness of $\ell^1{G}$.

It is open when $G$ is the Heisenberg group.

Motivation behind this question is proposition 2.1, theorem 3.1 and conjecture 3.6 in the paper here. Note that conjecture 3.6 is false ingle general, but for the most interesting case, i.e., $G$ is Heisenberg group, it is still open.