Most pythonic way to delete a file which may not exist

os.path.exists returns True for folders as well as files. Consider using os.path.isfile to check for whether the file exists instead.

A more pythonic way would be:

try:
    os.remove(filename)
except OSError:
    pass

Although this takes even more lines and looks very ugly, it avoids the unnecessary call to os.path.exists() and follows the python convention of overusing exceptions.

It may be worthwhile to write a function to do this for you:

import os, errno

def silentremove(filename):
    try:
        os.remove(filename)
    except OSError as e: # this would be "except OSError, e:" before Python 2.6
        if e.errno != errno.ENOENT: # errno.ENOENT = no such file or directory
            raise # re-raise exception if a different error occurred

I prefer to suppress an exception rather than checking for the file's existence, to avoid a TOCTTOU bug. Matt's answer is a good example of this, but we can simplify it slightly under Python 3, using contextlib.suppress():

import contextlib

with contextlib.suppress(FileNotFoundError):
    os.remove(filename)

If filename is a pathlib.Path object instead of a string, we can call its .unlink() method instead of using os.remove(). In my experience, Path objects are more useful than strings for filesystem manipulation.

Since everything in this answer is exclusive to Python 3, it provides yet another reason to upgrade.

As of Python 3.8, use missing_ok=True and pathlib.Path.unlink (docs here)

from pathlib import Path

my_file = Path("./dir1/dir2/file.txt")

# Python 3.8+
my_file.unlink(missing_ok=True)

# Python 3.7 and earlier
if my_file.exists():
    my_file.unlink()