Not clear/sharp font in Windows after connecting it thru Remote desktop for the 1st time

What helped me is to type the following in the Google Chrome's address bar :

about:restart

and press Enter. Chrome will restart and reopen all your tabs and your font smoothing should again work at this point.

Make sure "Font smoothing" is checked in the "Experience" tab (MS RDC Client), if it doesn't help, please log off current user from the start menu and try again.

I resolved by changing the profile in the Performance configuration tab of Remote Desktop, from automatic quality detection to 10 LAN (the Font Smoothing checkbox got activated):