Number of possible zero entries in orthogonal matrices
An interesting observation, but it doesn't pan out unfortunately! It already fails in dimension 3. Wikipedia has the following counterexample of a rotoinversion: $$ \begin{bmatrix} 0 & -0.8 & - 0.6 \\ 0.8 & -0.36 & 0.48 \\ 0.6&0.48&-0.64 \end{bmatrix} $$
(WolframAlpha agrees that this is indeed orthogonal, the example is from here)