One-liner to check whether an iterator yields at least one element?

any won't go beyond the first element if it's True. In case the iterator yields something false-ish you can write any(True for _ in iterator).

In Python 2.6+, if name sentinel is bound to a value which the iterator can't possibly yield,

if next(iterator, sentinel) is sentinel:
    print('iterator was empty')

If you have no idea of what the iterator might possibly yield, make your own sentinel (e.g. at the top of your module) with

sentinel = object()

Otherwise, you could use, in the sentinel role, any value which you "know" (based on application considerations) that the iterator can't possibly yield.

This isn't really cleaner, but it shows a way to package it in a function losslessly:

def has_elements(iter):
  from itertools import tee
  iter, any_check = tee(iter)
  try:
    any_check.next()
    return True, iter
  except StopIteration:
    return False, iter

has_el, iter = has_elements(iter)
if has_el:
  # not empty

This isn't really pythonic, and for particular cases, there are probably better (but less general) solutions, like the next default.

first = next(iter, None)
if first:
  # Do something

This isn't general because None can be a valid element in many iterables.