pandas dataframe remove first column by index code example

Example 1: remove 1st column pandas

df = df.drop(df.columns[[0, 1, 3]], axis=1)  # df.columns is zero-based pd.Index

Example 2: pandas drop columns by index

cols = [1,2,4,5,12]
df.drop(df.columns[cols],axis=1,inplace=True)