To convert an Excel file to PDF, simply operate Excel from win32com code example

Example: To convert an Excel file to PDF, simply operate Excel from win32com

import win32com.client
from pywintypes import com_error


# Path to original excel file
WB_PATH = r'C:\hoge\fuga\YearCalendar.xlsx'
# PDF path when saving
PATH_TO_PDF = r'C:\hoge\fuga\YearCalendar.pdf'


excel = win32com.client.Dispatch("Excel.Application")

excel.Visible = False

try:
    print('Start conversion to PDF')

    # Open
    wb = excel.Workbooks.Open(WB_PATH)

    # Specify the sheet you want to save by index. 1 is the first (leftmost) sheet.
    ws_index_list = [1,2,3,4,5,6,7,8,9,10,11,12]
    wb.WorkSheets(ws_index_list).Select()

    # Save
    wb.ActiveSheet.ExportAsFixedFormat(0, PATH_TO_PDF)
except com_error as e:
    print('failed.')
else:
    print('Succeeded.')
finally:
    wb.Close()
    excel.Quit()