Preventing double HTTP POST

Most of the answers so far have been client-side. On the server-side, you can generate a hidden field with a GUID when you first produce the form, and then record that GUID as a submitted form when the post is received. Check it before doing any more processing.

While JavaScript solutions can disable the submit button after it has been clicked, this will have no effect on those people who have JavaScript disabled. You should always make things work correctly without JavaScript before adding it in, otherwise there's no point as users will still be able to bypass the checks by just disabling JavaScript.

If the page where the form appears is dynamically generated, you can add a hidden field which contains some sort of sequence number, a hash, or anything unique. Then you have some server-side validation that will check if a request with that unique value has already come in. When the user submits the form, the unique value is checked against a list of "used" values. If it exists in the list, it's a dupe request and can be discarded. If it doesn't exist, then add it to the list and process as normal. As long as you make sure the value is unique, this guarantees the same form cannot be submitted twice.

Of course, if the page the form is on is not dynamically generated, then you'll need to do it the hard way on the server-side to check that the same information has not already been submitted.