PyCharm Python project No such file or directory

I faced the same problem and I solved it as follows

Fİle > Settings > project ["your project name"] > Python Interpretor >

Add Interpretor > System Interpretor > Apply

I try it and its working but you can chose local interpretor it can be work.

Started having the same issue after upgrading to PyCharm 3.4 - before that everything was working fine and after the update the same error. Also fixed by updating the path mappings: go to Run/Debug Configurations and manually define the Path mappings - Local path should be the path of your Django project and remote path the path to the project in the vagrant VM.

Another way to add the project context root in the preferences.

Preferences -> Project Structure -> Add Context Root