add head upon reading in pandas code example

Example 1: how to add headings to data in pandas

Cov = pd.read_csv("path/to/file.txt", sep='\t')
Frame=pd.DataFrame(Cov.values, columns = ["Sequence", "Start", "End", "Coverage"])
Frame.to_csv("path/to/file.txt", sep='\t')

Example 2: pandas heading

pd.read_csv("directory", heading = None)