Python and lmfit: How to fit multiple datasets with shared parameters?

I think you're most of the way there. You need to put the data sets into an array or structure that can be used in a single, global objective function that you give to minimize() and fits all data sets with a single set of Parameters for all the data sets. You can share this set among data sets as you like. Expanding on your example a bit, the code below does work to do a single fit to the 5 different Gaussian functions. For an example of tying parameters across data sets, I used nearly identical value for sigma the 5 datasets the same value. I created 5 different sigma Parameters ('sig_1', 'sig_2', ..., 'sig_5'), but then forced these to have the same values using a mathematical constraint. Thus there are 11 variables in the problem, not 15.

import numpy as np
import matplotlib.pyplot as plt
from lmfit import minimize, Parameters, report_fit

def gauss(x, amp, cen, sigma):
    "basic gaussian"
    return amp*np.exp(-(x-cen)**2/(2.*sigma**2))

def gauss_dataset(params, i, x):
    """calc gaussian from params for data set i
    using simple, hardwired naming convention"""
    amp = params['amp_%i' % (i+1)].value
    cen = params['cen_%i' % (i+1)].value
    sig = params['sig_%i' % (i+1)].value
    return gauss(x, amp, cen, sig)

def objective(params, x, data):
    """ calculate total residual for fits to several data sets held
    in a 2-D array, and modeled by Gaussian functions"""
    ndata, nx = data.shape
    resid = 0.0*data[:]
    # make residual per data set
    for i in range(ndata):
        resid[i, :] = data[i, :] - gauss_dataset(params, i, x)
    # now flatten this to a 1D array, as minimize() needs
    return resid.flatten()

# create 5 datasets
x  = np.linspace( -1, 2, 151)
data = []
for i in np.arange(5):
    params = Parameters()
    amp   =  0.60 + 9.50*np.random.rand()
    cen   = -0.20 + 1.20*np.random.rand()
    sig   =  0.25 + 0.03*np.random.rand()
    dat   = gauss(x, amp, cen, sig) + np.random.normal(size=len(x), scale=0.1)
    data.append(dat)

# data has shape (5, 151)
data = np.array(data)
assert(data.shape) == (5, 151)

# create 5 sets of parameters, one per data set
fit_params = Parameters()
for iy, y in enumerate(data):
    fit_params.add( 'amp_%i' % (iy+1), value=0.5, min=0.0,  max=200)
    fit_params.add( 'cen_%i' % (iy+1), value=0.4, min=-2.0,  max=2.0)
    fit_params.add( 'sig_%i' % (iy+1), value=0.3, min=0.01, max=3.0)

# but now constrain all values of sigma to have the same value
# by assigning sig_2, sig_3, .. sig_5 to be equal to sig_1
for iy in (2, 3, 4, 5):
    fit_params['sig_%i' % iy].expr='sig_1'

# run the global fit to all the data sets
result = minimize(objective, fit_params, args=(x, data))
report_fit(result)

# plot the data sets and fits
plt.figure()
for i in range(5):
    y_fit = gauss_dataset(fit_params, i, x)
    plt.plot(x, data[i, :], 'o', x, y_fit, '-')

plt.show()

For what it's worth, I would consider holding the multiple data sets in a dictionary or list of DataSet class instead of a multi-dimensional array. Anyway, I hope this helps get you going onto what you really need to do.

I've used simple approach: define a function firs n( = cargsnum) of arguments is common for all data set's other is individual {

def likelihood_common(var, xlist, ylist, mlist, cargsnum):
    cvars = var[:cargsnum]
    iargnum = [model.func_code.co_argcount - 1 - cargsnum for model in mlist]
    argpos = [cargsnum,] + list(np.cumsum(iargnum[:-1]) + cargsnum)
    args = [list(cvars) + list(var[pos:pos+iarg]) for pos, iarg in zip(argpos, iargnum)]
    res = [likelihood(*arg) for arg in zip(args, xlist, ylist, mlist)]
    return np.sum(res)

} here supposed that each data set have the same weight. The issue I faced in this approach is weary low computation speed and instability in case of large number of fitted parameters and data sets.