Python find elements in one list that are not in the other

TL;DR:
SOLUTION (1)

import numpy as np
main_list = np.setdiff1d(list_2,list_1)
# yields the elements in `list_2` that are NOT in `list_1`

SOLUTION (2) You want a sorted list

def setdiff_sorted(array1,array2,assume_unique=False):
    ans = np.setdiff1d(array1,array2,assume_unique).tolist()
    if assume_unique:
        return sorted(ans)
    return ans
main_list = setdiff_sorted(list_2,list_1)

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EXPLANATIONS:
(1) You can use NumPy's setdiff1d (array1,array2,assume_unique=False).

assume_unique asks the user IF the arrays ARE ALREADY UNIQUE.
If False, then the unique elements are determined first.
If True, the function will assume that the elements are already unique AND function will skip determining the unique elements.

This yields the unique values in array1 that are not in array2. assume_unique is False by default.

If you are concerned with the unique elements (based on the response of Chinny84), then simply use (where assume_unique=False => the default value):

import numpy as np
list_1 = ["a", "b", "c", "d", "e"]
list_2 = ["a", "f", "c", "m"] 
main_list = np.setdiff1d(list_2,list_1)
# yields the elements in `list_2` that are NOT in `list_1`

(2) For those who want answers to be sorted, I've made a custom function:

import numpy as np
def setdiff_sorted(array1,array2,assume_unique=False):
    ans = np.setdiff1d(array1,array2,assume_unique).tolist()
    if assume_unique:
        return sorted(ans)
    return ans

To get the answer, run:

main_list = setdiff_sorted(list_2,list_1)

---

SIDE NOTES:
(a) Solution 2 (custom function setdiff_sorted) returns a list (compared to an array in solution 1).

(b) If you aren't sure if the elements are unique, just use the default setting of NumPy's setdiff1d in both solutions A and B. What can be an example of a complication? See note (c).

(c) Things will be different if either of the two lists is not unique.
Say list_2 is not unique: list2 = ["a", "f", "c", "m", "m"]. Keep list1 as is: list_1 = ["a", "b", "c", "d", "e"]
Setting the default value of assume_unique yields ["f", "m"] (in both solutions). HOWEVER, if you set assume_unique=True, both solutions give ["f", "m", "m"]. Why? This is because the user ASSUMED that the elements are unique). Hence, IT IS BETTER TO KEEP assume_unique to its default value. Note that both answers are sorted.

pythonnumpy

You can use sets:

main_list = list(set(list_2) - set(list_1))

Output:

>>> list_1=["a", "b", "c", "d", "e"]
>>> list_2=["a", "f", "c", "m"]
>>> set(list_2) - set(list_1)
set(['m', 'f'])
>>> list(set(list_2) - set(list_1))
['m', 'f']

Per @JonClements' comment, here is a tidier version:

>>> list_1=["a", "b", "c", "d", "e"]
>>> list_2=["a", "f", "c", "m"]
>>> list(set(list_2).difference(list_1))
['m', 'f']