python remove all items from list that are in another code example

Example 1: delete element of a list from another list python

l1 = ["a", "b", "c", "d", "e", "f"]
l2 = ["b", "c", "e"]

l1 = [elt for elt in l1 if elt not in l2]
# l1 = ['a', 'd', 'f']

Example 2: delete all elements in list python

mylist = [1, 2, 3, 4]
mylist.clear()

print(mylist)
# []