scikit imsave 16 bit tiff save code example
Example: io.imsave 16 bit
import numpy as np
from skimage import io, exposure, img_as_uint, img_as_float
io.use_plugin('freeimage')
im = np.array([[1., 2.], [3., 4.]], dtype='float64')
im = exposure.rescale_intensity(im, out_range='float')
im = img_as_uint(im)
io.imsave('test_16bit.png', im)
im2 = io.imread('test_16bit.png')