Example 1: remove 1st column pandas
df = df.drop(df.columns[[0, 1, 3]], axis=1)
Example 2: how to drop a column by name in pandas
>>> midx = pd.MultiIndex(levels=[['lama', 'cow', 'falcon'],
... ['speed', 'weight', 'length']],
... codes=[[0, 0, 0, 1, 1, 1, 2, 2, 2],
... [0, 1, 2, 0, 1, 2, 0, 1, 2]])
>>> df = pd.DataFrame(index=midx, columns=['big', 'small'],
... data=[[45, 30], [200, 100], [1.5, 1], [30, 20],
... [250, 150], [1.5, 0.8], [320, 250],
... [1, 0.8], [0.3, 0.2]])
>>> df
big small
lama speed 45.0 30.0
weight 200.0 100.0
length 1.5 1.0
cow speed 30.0 20.0
weight 250.0 150.0
length 1.5 0.8
falcon speed 320.0 250.0
weight 1.0 0.8
length 0.3 0.2