Replace all particular values in a data frame

Here are a couple dplyr options:

library(dplyr)

# all columns:
df %>% 
  mutate_all(~na_if(., ''))

# specific column types:
df %>% 
  mutate_if(is.factor, ~na_if(., ''))

# specific columns:  
df %>% 
  mutate_at(vars(A, B), ~na_if(., ''))

# or:
df %>% 
  mutate(A = replace(A, A == '', NA))

# replace can be used if you want something other than NA:
df %>% 
  mutate(A = as.character(A)) %>% 
  mutate(A = replace(A, A == '', 'used to be empty'))

Since PikkuKatja and glallen asked for a more general solution and I cannot comment yet, I'll write an answer. You can combine statements as in:

> df[df=="" | df==12] <- NA
> df
     A    B
1  <NA> <NA>
2  xyz  <NA>
3  jkl  100

For factors, zxzak's code already yields factors:

> df <- data.frame(list(A=c("","xyz","jkl"), B=c(12,"",100)))
> str(df)
'data.frame':   3 obs. of  2 variables:
 $ A: Factor w/ 3 levels "","jkl","xyz": 1 3 2
 $ B: Factor w/ 3 levels "","100","12": 3 1 2

If in trouble, I'd suggest to temporarily drop the factors.

df[] <- lapply(df, as.character)

Like this:

> df[df==""]<-NA
> df
     A    B
1 <NA>   12
2  xyz <NA>
3  jkl  100