Resizing Images in VB.NET

Here is an article with full details on how to do this.

Private Sub btnScale_Click(ByVal sender As System.Object, _
    ByVal e As System.EventArgs) Handles btnScale.Click
    ' Get the scale factor.
    Dim scale_factor As Single = Single.Parse(txtScale.Text)

    ' Get the source bitmap.
    Dim bm_source As New Bitmap(picSource.Image)

    ' Make a bitmap for the result.
    Dim bm_dest As New Bitmap( _
        CInt(bm_source.Width * scale_factor), _
        CInt(bm_source.Height * scale_factor))

    ' Make a Graphics object for the result Bitmap.
    Dim gr_dest As Graphics = Graphics.FromImage(bm_dest)

    ' Copy the source image into the destination bitmap.
    gr_dest.DrawImage(bm_source, 0, 0, _
        bm_dest.Width + 1, _
        bm_dest.Height + 1)

    ' Display the result.
    picDest.Image = bm_dest
End Sub

[Edit]
One more on the similar lines.

You can simply use this one line code to resize your image in visual basic .net

Public Shared Function ResizeImage(ByVal InputImage As Image) As Image
        Return New Bitmap(InputImage, New Size(64, 64))
End Function

Where;

1. "InputImage" is the image you want to resize.
2. "64 X 64" is the required size you may change it as your needs i.e 32X32 etc.

This will re-size any image using the best quality with support for 32bpp with alpha. The new image will have the original image centered inside the new one at the original aspect ratio.

#Region " ResizeImage "
    Public Overloads Shared Function ResizeImage(SourceImage As Drawing.Image, TargetWidth As Int32, TargetHeight As Int32) As Drawing.Bitmap
        Dim bmSource = New Drawing.Bitmap(SourceImage)

        Return ResizeImage(bmSource, TargetWidth, TargetHeight)
    End Function

    Public Overloads Shared Function ResizeImage(bmSource As Drawing.Bitmap, TargetWidth As Int32, TargetHeight As Int32) As Drawing.Bitmap
        Dim bmDest As New Drawing.Bitmap(TargetWidth, TargetHeight, Drawing.Imaging.PixelFormat.Format32bppArgb)

        Dim nSourceAspectRatio = bmSource.Width / bmSource.Height
        Dim nDestAspectRatio = bmDest.Width / bmDest.Height

        Dim NewX = 0
        Dim NewY = 0
        Dim NewWidth = bmDest.Width
        Dim NewHeight = bmDest.Height

        If nDestAspectRatio = nSourceAspectRatio Then
            'same ratio
        ElseIf nDestAspectRatio > nSourceAspectRatio Then
            'Source is taller
            NewWidth = Convert.ToInt32(Math.Floor(nSourceAspectRatio * NewHeight))
            NewX = Convert.ToInt32(Math.Floor((bmDest.Width - NewWidth) / 2))
        Else
            'Source is wider
            NewHeight = Convert.ToInt32(Math.Floor((1 / nSourceAspectRatio) * NewWidth))
            NewY = Convert.ToInt32(Math.Floor((bmDest.Height - NewHeight) / 2))
        End If

        Using grDest = Drawing.Graphics.FromImage(bmDest)
            With grDest
                .CompositingQuality = Drawing.Drawing2D.CompositingQuality.HighQuality
                .InterpolationMode = Drawing.Drawing2D.InterpolationMode.HighQualityBicubic
                .PixelOffsetMode = Drawing.Drawing2D.PixelOffsetMode.HighQuality
                .SmoothingMode = Drawing.Drawing2D.SmoothingMode.AntiAlias
                .CompositingMode = Drawing.Drawing2D.CompositingMode.SourceOver

                .DrawImage(bmSource, NewX, NewY, NewWidth, NewHeight)
            End With
        End Using

        Return bmDest
    End Function
#End Region

Don't know much VB.NET syntax but here's and idea

Dim source As New Bitmap("C:\image.png") 
Dim target As New Bitmap(size.Width, size.Height, PixelFormat.Format24bppRgb)

Using graphics As Graphics = Graphics.FromImage(target)
    graphics.DrawImage(source, new Size(48, 48)) 
End Using