Runtime creation of generic Func<T>

You use Delegate.CreateDelegate, i.e. from a MethodInfo; below, I've hard-coded, but you would use some logic, or Expression, to get the actual creation method:

using System;
using System.Reflection;
class Foo {}

static class Program
{
    static Func<T> GetFactory<T>()
    {
        return (Func<T>)GetFactory(typeof(T));
    }
    static object GetFactory(Type type)
    {
        Type funcType = typeof(Func<>).MakeGenericType(type);
        MethodInfo method = typeof(Program).GetMethod("CreateFoo",
            BindingFlags.NonPublic | BindingFlags.Static);
        return Delegate.CreateDelegate(funcType, method);
    }
    static Foo CreateFoo() { return new Foo(); }
    static void Main()
    {
        Func<Foo> factory = GetFactory<Foo>();
        Foo foo = factory();
    }
}

For non-static methods, there is an overload of Delegate.CreateDelegate that accepts the target instance.