SELECT * EXCEPT

Create a view on the table which doesn't include the blob columns

As others have said, it is not a good idea to do this in a query because it is prone to issues when someone changes the table structure in the future. However, there is a way to do this... and I can't believe I'm actually suggesting this, but in the spirit of answering the ACTUAL question...

Do it with dynamic SQL... this does all the columns except the "description" column. You could easily turn this into a function or stored proc.

declare @sql varchar(8000),
    @table_id int,
    @col_id int

set @sql = 'select '

select @table_id = id from sysobjects where name = 'MY_Table'

select @col_id = min(colid) from syscolumns where id = @table_id and name <> 'description'
while (@col_id is not null) begin
    select @sql = @sql + name from syscolumns where id = @table_id and colid = @col_id

    select @col_id = min(colid) from syscolumns where id = @table_id and colid > @col_id and name <> 'description'
    if (@col_id is not null) set @sql = @sql + ','
    print @sql
end

set @sql = @sql + ' from MY_table'

exec @sql