Sequelize update with association

First you have to find model including sub model which you want to update. then you can get reference of sub model to update easily. i am posting an example for your reference. hope it will help.

var updateProfile = { name: "name here" };
var filter = {
  where: {
    id: parseInt(req.body.id)
  },
  include: [
    { model: Profile }
  ]
};

Product.findOne(filter).then(function (product) {
  if (product) {
    return product.Profile.updateAttributes(updateProfile).then(function (result) {
      return result;
    });
  } else {
    throw new Error("no such product type id exist to update");
  }
});

If you want to update both models(Product & Profile) at once. One of the approaches can be:

// this is an example of object that can be used for update
let productToUpdate = {
    amount: 'new product amount'
    Profile: {
        name: 'new profile name'
    }
};
Product
    .findById(productId)
    .then((product) => {
        if(!product) {
            throw new Error(`Product with id ${productId} not found`);
        }

        product.Profile.set(productToUpdate.Profile, null);
        delete productToUpdate.Profile; // We have to delete this object to not reassign values
        product.set(productToUpdate);

        return sequelize
            .transaction((t) => {
                return product
                    .save({transaction: t})
                    .then((updatedProduct) => updatedProduct.Profile.save());
            })
    })
    .then(() => console.log(`Product & Profile updated!`))