how to use 'where is not' in laravel eloquent code example

Example 1: laravel not in query

DB::table(..)->select(..)->whereNotIn('book_price', [100,200])->get();

Example 2: update query laravel

$update = \DB::table('student') ->where('id', $data['id']) ->limit(1) ->update( [ 'name' => $data['name'], 'address' => $data['address'], 'email' => $data['email'], 'contactno' => $data['contactno'] ]);