SSL backend error when using OpenSSL

helloworld2013's answer is correct, but the key is matching the SSL library that pycurl is expecting. The error will be something like:

pycurl: libcurl link-time ssl backend (<library>) is different from compile-time ssl backend (<library> or "none/other")

To fix it, you have to use the library pycurl is expecting. In my case, my error was "pycurl: libcurl link-time ssl backend (nss) is different from compile-time ssl backend (openssl)", so my fix was:

pip uninstall pycurl
export PYCURL_SSL_LIBRARY=nss
pip install pycurl

for most people

After reading their INSTALLATION file, I was able to solve my problem by setting an environment variable and did a reinstall

# remove existing `pycurl` installation 
pip uninstall pycurl

# export variable with your link-time ssl backend (which is openssl above)
export PYCURL_SSL_LIBRARY=openssl

# then, re-install `pycurl` with **no cache**
pip install pycurl --no-cache-dir

There could be other solution out there but this works perfectly for me on a virtualenv and pip installation.

Some people have a different error message complaining about nss instead of openssl

ImportError: pycurl: libcurl link-time ssl backend (nss)

(the key part is nss) so you have to do something different for this error message:

pip uninstall pycurl
pip install --no-cache-dir --compile --compile-options="--with-nss" pycurl

With macOS 10.13, a brew-installed openSSL, and virtualenv, I was successful with:

# cd to your virtualenv, then…
pip uninstall pycurl
export PYCURL_SSL_LIBRARY=openssl
export LDFLAGS=-L/usr/local/opt/openssl/lib
export CPPFLAGS=-I/usr/local/opt/openssl/include
pip install pycurl --compile --no-cache-dir