Swap prime exponents with their neighbours

Jelly, 10 bytes

ÆE;0s2UFÆẸ

Try it online! or verify all test cases.

How it works

ÆE;0s2UFÆẸ  Main link. Argument: n

ÆE          Yield the exponents of n's prime factorization.
  ;0        Append a zero.
    s2      Split into pairs.
      U     Upend; reverse each pair.
       F    Flatten the resulting list of pairs.
        ÆẸ  Convert the prime exponents to integer.

Jelly, 17 16 11 bytes

5 bytes thanks to Dennis.

ÆfÆC’^1‘ÆNP

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Explanation

ÆfÆC’^1‘ÆNP   Main monadic chain. Argument: n

Æf            Yield the prime factors of n.
  ÆC          For each factor, count the number of primes below it.
              This effectively yields their indices.
    ’         Decrement [each] by 1.
     ^1       Xor with 1
       ‘      Increment [each] by 1.
        ÆN    Find their corresponding primes.
          P   Yield their product.

Previous 16-byte version

ÆnÆRiЀÆf’^1‘ÆNP

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Explanation

ÆnÆRiЀÆf’^1‘ÆNP   Main monadic chain. Argument: n

Æn                 Yield the next prime from n.
  ÆR               Yield all primes from 2 to it.
       Æf          Yield prime factors of n
    iЀ            Yield their index in the prime list.
         ’         Decrement [each] by 1.
          ^1       Xor with 1
            ‘      Increment [each] by 1.
             ÆN    Find their corresponding primes.
               P   Yield their product.

Previous 17-byte version:

ÆnÆR©iЀÆf’^1‘ị®P

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Explanation

ÆnÆR©iЀÆf’^1‘ị®P   Main monadic chain. Argument: n

Æn                  Yield the next prime from n.
  ÆR                Yield all primes from 2 to it.
    ©               Store to register.
        Æf          Yield prime factors of n
     iЀ            Yield their index in the prime list.
          ’         Decrement [each] by 1.
           ^1       Xor with 1
             ‘      Increment [each] by 1.
              ị®    Find their corresponding primes in
                    the list in register.
                P   Yield their product.

Python 2, 149 139 bytes

10 bytes thanks to Dennis.

n=input()
p=f=1;w=[2]
while w[-1]<=n:f*=p;p+=1;w+=[p]*(-~f%p<1)
r=p=1;w=w[1:]
while n>1:
    p+=1
    while n%p<1:n/=p;r*=w[w.index(p)^1]
print r