Tuple.Create() vs new Tuple

The benefit of Tuple.Create is that you can usually omit the type arguments, eg. Tuple.Create(1,2) is briefer than new Tuple<int,int>(1,2).

If you try omitting the type arguments from the constructor new Tuple(1,2) you will see error CS0712 "Cannot create an instance of the static class 'Tuple""

Personally, I find Tuple.Create() less verbose and easier to read.

There's no difference, under the hood. The Tuple.Create() overloaded methods are just a bunch of static methods that call the first version you posted:

public static class Tuple
{
    public static Tuple<T1> Create<T1>(T1 item1) {
        return new Tuple<T1>(item1);
    }

    public static Tuple<T1, T2> Create<T1, T2>(T1 item1, T2 item2) {
        return new Tuple<T1, T2>(item1, item2);
    }

    public static Tuple<T1, T2, T3> Create<T1, T2, T3>(T1 item1, T2 item2, T3 item3) {
        return new Tuple<T1, T2, T3>(item1, item2, item3);
    }

    ...

I suppose one benefit is that, since you don't have to specify the type with Tuple.Create, you can store anonymous types for which you otherwise wouldn't be able to say what the type is.

public class Person
{
    public string Name { get; set; }
    public int Height { get; set; }
    public DateTime BirthDate { get; set; }
}

var people = new List<Person>
{
    new Person { Name = "Bob", Height = 72, BirthDate = new DateTime(1984,1,1) },
    new Person { Name = "Mary", Height = 64, BirthDate = new DateTime(1980,2,2) }
};

var oneAnonList = people.Select(x => new { x.Name, x.BirthDate });
var twoAnonList = people.Select(x => new { x.Height, x.Name });

var myTuple = Tuple.Create(oneAnonList, twoAnonList);

This creates a Tuple with two anonymous types, the first is a new { string Name, DateTime BirthDate } and the second is a new { int Height, string Name }.

There's still not too terribly much you can do with that, since to pass it to another method, you'd still need to be able to define the "type" of the parameter. So it really comes down to convenience.