Upgrade chip in Deus Ex: Human Revolution?
It does matter. Spoiler:
Just before you fight the third boss, Zhao uses something on you. If you have the upgraded biochip, you essentially have a permanent EMP. Your HUD is messed up, so you don't have a radar, health/battery meter, ammo, etc. I found I was able to use augmentations though (such as looking through walls). I just didn't know how much battery power I had left.