Upgrade to Visual Studio 2015 and now can't hit break points in debugging

I had a similar problem, when I created a new build configuration. After hunting around settings in VS2015, I noticed that there were no *.pdb files in my build output. Obviously, debugging would not work if there were *.pdb files.

The fix for me was to go into every project's properties -> 'build' page -> click the "advanced" button at the bottom of the page -> In the dialog's 'Output' section, I set "debug info" to equal "full".

Basically, I created a new solution and project and copied all the build properties into the solution that the debugger was not stopping at break points anymore. In addition to the setting above, I also changed the following setting to match the default debug settings:

• I set on the same advanced page "Internal Compiler Error Reporting" to "prompt"
• In the main 'build' page, I checked in the 'general' section "Define DEBUG constant" and "Define TRACE constant"

I solved this problem when checked Options->Debugging->General->Suppress jit optimization on module load. Before I did that I have also unchecked Tools->Options "Projects and Solutions" "Build and Run" "Only build startup projects and dependencies on run". Don't know if that has any reason why it works after suppress jit is unchecked.

My situation was that I have enabled "Optimize code" in the project properties.