value.replace(/[^0-9.,]+/g, '') code example
Example: this.value=this.value.replace(/[^0-9]/g,'')
<asp:TextBox ID="txtJobNo" runat="server" class="TextBoxStyle" onkeyup="this.value=this.value.replace(/[^0-9]/g,'')" />
<asp:TextBox ID="txtJobNo" runat="server" class="TextBoxStyle" onkeyup="this.value=this.value.replace(/[^0-9]/g,'')" />