What is the difference between root.destroy() and root.quit()?

root.quit() causes mainloop to exit. The interpreter is still intact, as are all the widgets. If you call this function, you can have code that executes after the call to root.mainloop(), and that code can interact with the widgets (for example, get a value from an entry widget).

Calling root.destroy() will destroy all the widgets and exit mainloop. Any code after the call to root.mainloop() will run, but any attempt to access any widgets (for example, get a value from an entry widget) will fail because the widget no longer exists.

quit() stops the TCL interpreter. This is in most cases what you want, because your Tkinter-app will also stop. It can be a problem, if you e.g. call your app from idle. idle is itself a Tkinker-app, so if you call quit() in your app and the TCL interpreter gets terminated, idle will also terminate (or get confused ).

destroy() just terminates the mainloop and deletes all widgets. So it seems to be safer if you call your app from another Tkinter app, or if you have multiple mainloops."

taken from http://www.daniweb.com/forums/thread66698.html