What is the fastest way to clear cache and cookies in Google Chrome?

I'm on Mac and this is the shortcut: Shift+Command+Delete.

On Windows, it's Ctrl+Shift+Delete.

This link gives you all shortcuts for Chrome: Chrome Support: Mac keyboard shortcuts

I use the Chrome extension Clear Cache. It does the same as Chrome's own Clear Browsing Data dialogue, but you can assign a short cut (or just use the extension button next to the address bar) to it. I have mine set up to reload the page and remove any cache from the last hour by pressing Ctrl+Shft+R. It saves me a lot of time, not having to enter Chrome's dialogue, when editing a web site.

While this doesn't apply to the cookies, in the F12 Developer Tools setting, you can choose to disable cache while the Developer Tools is open.

Open Developer Tools and select the settings button in the top right corner. On the General page you can check the box.